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Figure 2 More recently, a multiple hits theory has been proposed, with the addition of other pathogenic factors in NAFLD development: low-grade chronic inflammation, genetic and epigenetic mutations, and intestinal microbiota

Swanson JM et al (1999): Acute tolerance to methylphenidate in the treatment of ADHD in children

While combining nutraceuticals with pharmaceuticals can amplify efficacy (e.g., enhancing drug absorption) or enable dose reduction (87, 89, 90), such synergies require meticulous scrutiny

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